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Answer:

In their essays, students should apply the remark to both Lady Macbeth’s condition and to the situation of Macbeth’s realm. For example, in discussing Lady Macbeth, they might feel that her murderous deeds and cold-blooded attitude are unnatural and so produce her unnatural waking sleep. As far as the condition in Macbeth’s realm is concerned, students might say that the unnatural murder of Duncan and the unnatural succession of Macbeth to the throne can only be followed by further unnatural acts of tyranny.