A report shows that individuals who misuse opioids over time often experience poor sleep, low energy, and changes in appetite. How does long-term opioid misuse lead to these effects?

Sleep, energy, and appetite are basic functions regulated by the body. Long-term opioid misuse can interfere with those regulatory systems, leading to changes in these functions. Therefore, “Long-term use disrupts how the body regulates basic functions” best explains the effects; the other choices focus on pain response or substance processing rather than these broader changes.

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