A student reads that opioid misuse can lead to anxiety, depression, and strong cravings over time. How do these effects relate to changes in the brain?

Opioids can change the brain’s chemical signaling when used over time. These changes can disrupt systems involved in regulating mood and reward, contributing to anxiety, depression, and strong cravings. Therefore, the best answer is “Long-term use alters brain chemistry and affects mood regulation.”

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