A report shows that individuals who misuse opioids over time are at greater risk of overdose compared to those who do not misuse them. Why does long-term opioid misuse increase the risk of overdose?

Long-term opioid misuse can lead to tolerance and dependence, which may prompt a person to take larger or more frequent doses. Taking unsafe amounts increases the risk of overdose. The correct choice is “Repeated misuse increases the chance of taking unsafe amounts over time.”

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