A person who misuses opioids over time needs higher doses to feel the same effect. What is the best explanation for this change?

With repeated opioid use, the body adapts to the drug, so the same dose has a weaker effect. This is called tolerance, and a person may need a higher dose to feel the same effect. The best choice is “The body develops tolerance and requires more of the drug.”

AI-written and checked against the verified answer.