Fentanyl is about 50 times stronger than heroin and 100 times stronger than morphine. Why does this increase the risk of overdose?

A drug that is much more potent can cause a strong effect at a much smaller dose. With fentanyl, a small dosing error can therefore produce dangerously powerful effects, increasing the risk of overdose. Choice B, “Smaller amounts can produce much stronger effects on the body,” describes this; choice C reverses the relationship.

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